Result
- Term Label: sequence-specific DNA binding transcription factor activity
- Term Accession: 0003700
- Term IRI: http://purl.obolibrary.org/obo/GO_0003700
- Definition: A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
Annotations
- in_subset: goslim_candida; goslim_chembl; goslim_drosophila; goslim_yeast; goslim_agr; goslim_metagenomics; goslim_mouse; goslim_plant
- has_alternative_id: GO:0001071; GO:0000130; GO:0001199; GO:0001130; GO:0001204; GO:0001151; GO:0001131
- has_exact_synonym: DNA binding transcription factor activity; sequence-specific DNA binding transcription factor activity; gene-specific transcription factor activity
- has_obo_namespace: molecular_function
- id: GO:0003700
- created_by: krc
- creation_date: 2010-10-21T04:37:54Z
- has_broad_synonym: transcription factor activity; nucleic acid binding transcription factor activity
- has_narrow_synonym: transcription factor activity, metal ion regulated sequence-specific DNA binding; transcription factor activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding; sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity; bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding; transcription factor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding; bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity; transcription factor activity, bacterial-type RNA polymerase transcription enhancer sequence-specific binding; bacterial-type DNA binding transcription factor activity; bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding; metal ion regulated sequence-specific DNA binding transcription factor activity; metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity; bacterial-type RNA polymerase transcription enhancer sequence-specific DNA binding transcription factor activity
- term tracker item: https://github.com/geneontology/go-ontology/issues/15704; https://github.com/geneontology/go-ontology/issues/16534; https://github.com/geneontology/go-ontology/issues/20253
- comment: Usage guidance: Most DNA-binding transcription factors do not have enzymatic activity. The presence of specific DNA-binding domains known to be present in DNA-binding transcription factors (HOX, GATA etc) should be used to help decide whether a protein is a DNA binding transcription factor or a coregulator. If a protein has an enzymatic activity (for example, ubiquitin ligase, histone acetyl transferase) and no known DNA binding domain, consider annotating to GO:0003712 transcription coregulator activity. Special care should be taken with proteins containing zinc fingers, Myb/SANT and ARID domains, since only a subset of proteins containing these domains directly and selectively bind to regulatory DNA motifs in cis-regulatory regions.
Links
- Download: EG3S.owl
- AmiGO: AmiGO Gene Ontology Browser
- Ontobee: http://purl.obolibrary.org/obo/GO_0003700
