- Term Label: sequence-specific DNA binding transcription factor activity
- Term Accession: 0003700
- Term IRI: http://purl.obolibrary.org/obo/GO_0003700
- Definition: A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
goslim_chembl; goslim_agr; goslim_yeast; goslim_generic; goslim_metagenomics; goslim_mouse; goslim_plant; goslim_aspergillus; goslim_candida
GO:0000130; GO:0001199; GO:0001071
DNA binding transcription factor activity; gene-specific transcription factor activity; sequence-specific DNA binding transcription factor activity
transcription factor activity; nucleic acid binding transcription factor activity
transcription factor activity, metal ion regulated sequence-specific DNA binding; metal ion regulated sequence-specific DNA binding transcription factor activity
comment: Curator guidance: Note that most DNA binding transcription factors do not have enzymatic activity. If a protein has an enzymatic activity (for example, ubiquitin ligase, histone acetyl transferase), consider annotating to GO:0003712 transcription coregulator activity. The presence of specific domains known to be present in transcription factors (HOX, GATA etc) should be used to help decide whether a protein is a DNA binding transcription factor or a coregulator.
Changed definition see https://github.com/geneontology/go-ontology/issues/15704
Merged term see https://github.com/geneontology/go-ontology/issues/16534