has_related_synonym
has_narrow_synonym
has_alternative_id
in_subset
imported from
database_cross_reference
has_broad_synonym
consider
has_obo_namespace
has_exact_synonym
part of
has_part
occurs in
regulates
negatively regulates
positively regulates
protein import into nucleus, translocation
GO:0000060
Note that 'vectorial' is used in the definition in the mathematical and physical sense of pertaining to 'a quantity having direction as well as magnitude, especially as determining the position of one point in space relative to another. Note that 'translocation' is sometimes used in the literature to refer to the entire process of protein import into the nucleus, but in GO refers specifically to the step in which a cargo-carrier protein complex moves through the nuclear pore complex.
biological_process
protein import into cell nucleus, translocation
protein translocation during protein import into nucleus
protein translocation during protein transport from cytoplasm to nucleus
protein translocation during protein-nucleus import
protein transport from cytoplasm to nucleus, translocation
protein-nucleus import, translocation
negative regulation of transcription from RNA polymerase II promoter
GO:0000122
GO:0010553
GO:0045816
biological_process
down regulation of global transcription from RNA polymerase II promoter
down regulation of transcription from RNA polymerase II promoter
down-regulation of global transcription from RNA polymerase II promoter
down-regulation of transcription from RNA polymerase II promoter
downregulation of global transcription from RNA polymerase II promoter
downregulation of transcription from RNA polymerase II promoter
inhibition of global transcription from RNA polymerase II promoter
inhibition of transcription from RNA polymerase II promoter
negative regulation of gene-specific transcription from RNA polymerase II promoter
negative regulation of global transcription from Pol II promoter
negative regulation of transcription from Pol II promoter
negative regulation of transcription from RNA polymerase II promoter, global
cell fraction
1
GO:0000267
GO:0005575
This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component.
cellular_component
transcription regulatory region sequence-specific DNA binding
angiogenesis
GO:0001525
Wikipedia:Angiogenesis
biological_process
blood vessel formation from pre-existing blood vessels
blood vessel development
GO:0001568
biological_process
response to hypoxia
GO:0001666
Note that this term should not be confused with 'response to anoxia ; GO:0034059'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%.
biological_process
response to hypoxic stress
response to lowered oxygen tension
cell activation
GO:0001775
biological_process
vasculature development
GO:0001944
biological_process
vascular system development
wound healing involved in inflammatory response
GO:0002246
biological_process
healing during inflammatory response
inflammatory response wound healing
immune system process
GO:0002376
Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501). This term was added by GO_REF:0000022.
Wikipedia:Immune_system
biological_process
immune system development
GO:0002520
biological_process
leukocyte differentiation
myeloid leukocyte differentiation
positive regulation of myeloid leukocyte differentiation
GO:0002763
activation of myeloid leukocyte differentiation
biological_process
stimulation of myeloid leukocyte differentiation
up regulation of myeloid leukocyte differentiation
up-regulation of myeloid leukocyte differentiation
upregulation of myeloid leukocyte differentiation
molecular_function
GO:0003674
GO:0005554
Note that, in addition to forming the root of the molecular function ontology, this term is recommended for use for the annotation of gene products whose molecular function is unknown. Note that when this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this.
molecular function
molecular_function
DNA binding
GO:0003677
microtubule/chromatin interaction
molecular_function
plasmid binding
sequence-specific DNA binding transcription factor activity
GO:0000130
GO:0003700
molecular_function
transcription factor activity
RNA polymerase II transcription factor activity
1
GO:0000981
GO:0000991
GO:0001076
GO:0003702
GO:0006366
This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
molecular_function
GTPase activity
ARF small monomeric GTPase activity
GO:0003924
RHEA:19672
RHEB small monomeric GTPase activity
Rab small monomeric GTPase activity
Ran small monomeric GTPase activity
Ras small monomeric GTPase activity
Reactome:REACT_100432
Reactome:REACT_100708
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Reactome:REACT_102040
Reactome:REACT_102208
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Reactome:REACT_104739
Reactome:REACT_105323
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Reactome:REACT_108837
Reactome:REACT_109360
Reactome:REACT_109897
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Reactome:REACT_110557
Reactome:REACT_110859
Reactome:REACT_110879
Reactome:REACT_110931
Reactome:REACT_111994
Reactome:REACT_112104
Reactome:REACT_112254
Reactome:REACT_112389
Reactome:REACT_112587
Reactome:REACT_112651
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Reactome:REACT_113952
Reactome:REACT_113954
Reactome:REACT_114148
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Reactome:REACT_114188
Reactome:REACT_114210
Reactome:REACT_114331
Reactome:REACT_114379
Reactome:REACT_114384
Reactome:REACT_114532
Reactome:REACT_114620
Reactome:REACT_114824
Reactome:REACT_115229
Reactome:REACT_115324
Reactome:REACT_12396
Reactome:REACT_12397
Reactome:REACT_12456
Reactome:REACT_12612
Reactome:REACT_15316
Reactome:REACT_15335
Reactome:REACT_15449
Reactome:REACT_15495
Reactome:REACT_19123
Reactome:REACT_19178
Reactome:REACT_19186
Reactome:REACT_19194
Reactome:REACT_19219
Reactome:REACT_19255
Reactome:REACT_19317
Reactome:REACT_22359
Reactome:REACT_28065
Reactome:REACT_28251
Reactome:REACT_28269
Reactome:REACT_29162
Reactome:REACT_30456
Reactome:REACT_30463
Reactome:REACT_30562
Reactome:REACT_30687
Reactome:REACT_30707
Reactome:REACT_30942
Reactome:REACT_31226
Reactome:REACT_31474
Reactome:REACT_31530
Reactome:REACT_31599
Reactome:REACT_31709
Reactome:REACT_31727
Reactome:REACT_31850
Reactome:REACT_32006
Reactome:REACT_32028
Reactome:REACT_32914
Reactome:REACT_33948
Reactome:REACT_34113
Reactome:REACT_34480
Reactome:REACT_34592
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Reactome:REACT_348
Reactome:REACT_36834
Reactome:REACT_37542
Reactome:REACT_552
Reactome:REACT_6171
Reactome:REACT_712
Reactome:REACT_75799
Reactome:REACT_77032
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Reactome:REACT_81879
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Reactome:REACT_82704
Reactome:REACT_83308
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Reactome:REACT_84696
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Reactome:REACT_86760
Reactome:REACT_86972
Reactome:REACT_87409
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Reactome:REACT_87653
Reactome:REACT_87661
Reactome:REACT_88045
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Reactome:REACT_89231
Reactome:REACT_89292
Reactome:REACT_89416
Reactome:REACT_89668
Reactome:REACT_89763
Reactome:REACT_90050
Reactome:REACT_90064
Reactome:REACT_90517
Reactome:REACT_90703
Reactome:REACT_91199
Reactome:REACT_91588
Reactome:REACT_92176
Reactome:REACT_92197
Reactome:REACT_92198
Reactome:REACT_92450
Reactome:REACT_93249
Reactome:REACT_93305
Reactome:REACT_93641
Reactome:REACT_93742
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Reactome:REACT_94095
Reactome:REACT_94305
Reactome:REACT_94760
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Reactome:REACT_95563
Reactome:REACT_96019
Reactome:REACT_96132
Reactome:REACT_96223
Reactome:REACT_96612
Reactome:REACT_96881
Reactome:REACT_97284
Reactome:REACT_97405
Reactome:REACT_97595
Reactome:REACT_97794
Reactome:REACT_98431
Reactome:REACT_98556
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Rho small monomeric GTPase activity
Sar small monomeric GTPase activity
dynamin GTPase activity
heterotrimeric G-protein GTPase activity
heterotrimeric G-protein GTPase, alpha-subunit
heterotrimeric G-protein GTPase, beta-subunit
heterotrimeric G-protein GTPase, gamma-subunit
hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement
molecular_function
protein-synthesizing GTPase activity
protein-synthesizing GTPase activity, elongation
protein-synthesizing GTPase activity, initiation
protein-synthesizing GTPase activity, termination
signal-recognition-particle GTPase activity
small monomeric GTPase activity
tubulin GTPase activity
receptor binding
GO:0005102
Wikipedia:Ligand_(biochemistry)
molecular_function
receptor ligand
receptor-associated protein activity
cytokine activity
GO:0005125
autocrine activity
molecular_function
paracrine activity
cellular_component
GO:0005575
GO:0008372
NIF_Subcellular:sao-1337158144
NIF_Subcellular:sao1337158144
Note that, in addition to forming the root of the cellular component ontology, this term is recommended for use for the annotation of gene products whose cellular component is unknown. Note that when this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this.
cell or subcellular entity
cellular component
cellular_component
subcellular entity
extracellular region
GO:0005576
Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'.
Wikipedia:Extracellular
cellular_component
extracellular
extracellular space
GO:0005615
NIF_Subcellular:sao1425028079
Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism that are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term.
cellular_component
intercellular space
intracellular
cell
membrane fraction
1
GO:0005624
GO:0016020
This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component.
cellular_component
insoluble fraction
1
GO:0005575
GO:0005626
This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component.
cellular_component
particle-bound
cytoplasm
Golgi apparatus
GO:0005794
Golgi
Golgi complex
Golgi ribbon
NIF_Subcellular:sao451912436
Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon.
Wikipedia:Golgi_apparatus
cellular_component
cytosol
GO:0005829
NIF_Subcellular:sao101633890
Wikipedia:Cytosol
cellular_component
plasma membrane
GO:0005886
GO:0005904
NIF_Subcellular:sao1663586795
Wikipedia:Cell_membrane
bacterial inner membrane
cell membrane
cellular membrane
cellular_component
cytoplasmic membrane
inner endospore membrane
juxtamembrane
plasma membrane lipid bilayer
plasmalemma
integral component of plasma membrane
GO:0005887
cellular_component
integral to plasma membrane
fructose metabolic process
GO:0006000
Wikipedia:Fructose
biological_process
fructose metabolism
DNA metabolic process
transcription, DNA-templated
DNA-dependent transcription
GO:0006350
GO:0006351
GO:0061018
GO:0061022
Wikipedia:Transcription_(genetics)
biological_process
cellular transcription
cellular transcription, DNA-dependent
transcription
transcription regulator activity
transcription, DNA-dependent
regulation of transcription, DNA-templated
GO:0006355
GO:0032583
GO:0045449
GO:0061019
biological_process
regulation of cellular transcription, DNA-dependent
regulation of gene-specific transcription
regulation of transcription, DNA-dependent
transcriptional control
regulation of transcription from RNA polymerase II promoter
GO:0006357
GO:0006358
GO:0010551
biological_process
global transcription regulation from Pol II promoter
regulation of gene-specific transcription from RNA polymerase II promoter
regulation of global transcription from Pol II promoter
regulation of transcription from Pol II promoter
regulation of transcription from RNA polymerase II promoter, global
transcription from RNA polymerase II promoter
protein complex assembly
GO:0006461
biological_process
chaperone activity
protein complex formation
protein targeting
protein import into nucleus
cellular calcium ion homeostasis
GO:0006874
biological_process
regulation of calcium ion concentration
cellular metal ion homeostasis
GO:0006875
biological_process
cellular heavy metal ion homeostasis
nucleocytoplasmic transport
apoptotic process
movement of cell or subcellular component
GO:0006928
Note that in GO cellular components include whole cells (cell is_a cellular component).
biological_process
cell movement
cellular component motion
cellular component movement
chemotaxis
GO:0006935
Wikipedia:Chemotaxis
biological_process
taxis in response to chemical stimulus
response to stress
GO:0006950
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
biological_process
response to abiotic stress
response to biotic stress
defense response
GO:0002217
GO:0006952
GO:0042829
antimicrobial peptide activity
biological_process
defence response
defense/immunity protein activity
physiological defense response
inflammatory response
GO:0006954
Inflammation
This term was improved by GO_REF:0000022. It was moved.
Wikipedia:Inflammation
biological_process
immune response
GO:0006955
This term was improved by GO_REF:0000022. It was redefined and moved.
biological_process
mitochondrion organization
GO:0007005
biological_process
mitochondria organization
mitochondrion organisation
mitochondrion organization and biogenesis
cell communication
cell adhesion
GO:0007155
Wikipedia:Cell_adhesion
biological_process
cell adhesion molecule activity
enzyme linked receptor protein signaling pathway
GO:0007167
biological_process
enzyme linked receptor protein signalling pathway
transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007178
biological_process
transmembrane receptor protein serine/threonine kinase signalling pathway
I-kappaB kinase/NF-kappaB signaling
multicellular organismal development
aging
GO:0007568
GO:0016280
Wikipedia:Aging
ageing
biological_process
response to nutrient
GO:0007584
biological_process
nutritional response pathway
response to nutrients
digestion
behavior
GO:0007610
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
Wikipedia:Behavior
behavioral response to stimulus
behaviour
behavioural response to stimulus
biological_process
locomotory behavior
GO:0007626
behavior via locomotion
biological_process
locomotion in response to stimulus
locomotory behavioral response to stimulus
locomotory behaviour
locomotory behavioural response to stimulus
chemokine activity
GO:0008009
See also the molecular function term 'cytokine activity ; GO:0005125'.
molecular_function
growth factor activity
GO:0008083
molecular_function
biological_process
GO:0000004
GO:0007582
GO:0008150
Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. Note that when this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this.
Wikipedia:Biological_process
biological process
biological_process
physiological process
cell death
GO:0008219
This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide) show that cell death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Also, if experimental data suggest that a gene product influences cell death indirectly, rather than being involved in the death process directly, consider annotating to a 'regulation' term.
accidental cell death
biological_process
necrosis
cell proliferation
GO:0008283
This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms.
biological_process
positive regulation of cell proliferation
GO:0008284
activation of cell proliferation
biological_process
stimulation of cell proliferation
up regulation of cell proliferation
up-regulation of cell proliferation
upregulation of cell proliferation
negative regulation of cell proliferation
GO:0008285
biological_process
down regulation of cell proliferation
down-regulation of cell proliferation
downregulation of cell proliferation
inhibition of cell proliferation
apoptotic mitochondrial changes
GO:0008637
This term was created to reflect the fundamental role of the mitochondrial compartment in apoptosis. Most processes under this node occur during the signaling phase of apoptosis, but e.g. GO:0043653 'mitochondrial fragmentation involved in apoptotic process' cannot be confidently placed under the signaling phase. For this reason, the parent term GO:0008637 'apoptotic mitochondrial changes' is not linked to the signaling or execution phase specifically, but its descendants are when current knowledge allows for it.
biological_process
biosynthetic process
GO:0009058
Wikipedia:Anabolism
anabolism
biological_process
biosynthesis
formation
synthesis
macromolecule biosynthetic process
GO:0009059
GO:0043284
biological_process
biopolymer biosynthetic process
macromolecule anabolism
macromolecule biosynthesis
macromolecule formation
macromolecule synthesis
response to radiation
GO:0009314
Note that 'radiation' refers to electromagnetic radiation of any wavelength.
biological_process
response to electromagnetic radiation stimulus
response to radiation stimulus
response to wounding
GO:0002245
GO:0009611
biological_process
physiological response to wounding
response to bacterium
GO:0009617
GO:0009618
GO:0009680
biological_process
response to bacteria
response to abiotic stimulus
GO:0009628
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
biological_process
response to abiotic stress
response to hormone
GO:0009725
biological_process
growth regulator
response to hormone stimulus
regulation of biosynthetic process
GO:0009889
biological_process
regulation of anabolism
regulation of biosynthesis
regulation of formation
regulation of synthesis
negative regulation of biosynthetic process
GO:0009890
biological_process
down regulation of biosynthetic process
down-regulation of biosynthetic process
downregulation of biosynthetic process
inhibition of biosynthetic process
negative regulation of anabolism
negative regulation of biosynthesis
negative regulation of formation
negative regulation of synthesis
negative regulation of metabolic process
GO:0009892
biological_process
down regulation of metabolic process
down-regulation of metabolic process
downregulation of metabolic process
inhibition of metabolic process
negative regulation of metabolism
external side of plasma membrane
GO:0009897
cellular_component
external leaflet of plasma membrane
juxtamembrane
outer surface of cytoplasmic membrane
cytoplasmic side of plasma membrane
GO:0009898
cellular_component
internal leaflet of plasma membrane
internal side of plasma membrane
juxtamembrane
cell surface
GO:0009928
GO:0009929
GO:0009986
Note that this term is intended to annotate gene products that are attached (integrated or loosely bound) to the plasma membrane or cell wall.
cell associated
cell bound
cellular_component
cellular process
GO:0008151
GO:0009987
GO:0050875
biological_process
cell growth and/or maintenance
cell physiology
cellular physiological process
response to extracellular stimulus
GO:0009991
biological_process
response to organic substance
GO:0010033
biological_process
gene expression
regulation of macromolecule biosynthetic process
GO:0010556
biological_process
negative regulation of macromolecule biosynthetic process
GO:0010558
biological_process
negative regulation of macromolecule metabolic process
GO:0010605
biological_process
negative regulation of gene expression
GO:0010629
biological_process
regulation of cell death
GO:0010941
biological_process
positive regulation of cell death
GO:0010942
biological_process
programmed cell death
induction of programmed cell death
GO:0012502
GO:0012503
biological_process
induction of non-apoptotic programmed cell death
induction of nonapoptotic programmed cell death
endomembrane system
vesicle membrane
GO:0012506
NIF_Subcellular:sao1153182838
cellular_component
peptide transport
membrane
GO:0016020
Wikipedia:Biological_membrane
cellular_component
cytoplasmic membrane-bounded vesicle
GO:0016023
cellular_component
cytoplasmic membrane bounded vesicle
cytoplasmic membrane-enclosed vesicle
viral process
cellular component organization
GO:0016043
GO:0044235
GO:0071842
biological_process
cell organisation
cell organization and biogenesis
cellular component organisation at cellular level
cellular component organisation in other organism
cellular component organization at cellular level
cellular component organization in other organism
death
GO:0016265
See also the biological process term 'apoptosis ; GO:0006915'.
Wikipedia:Death
biological_process
single organismal cell-cell adhesion
GO:0016337
biological_process
catenin complex
GO:0016342
cellular_component
cell migration
GO:0016477
Wikipedia:Cell_migration
biological_process
cytoplasmic transport
transcription repressor activity
1
GO:0000988
GO:0001071
GO:0016564
GO:0045892
This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
molecular_function
negative transcriptional regulator activity
transcriptional repressor activity
viral life cycle
viral genome replication
regulation of nucleobase-containing compound metabolic process
GO:0019219
biological_process
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
regulation of metabolic process
GO:0019222
biological_process
regulation of metabolism
extrinsic component of plasma membrane
regulation of cell-cell adhesion
GO:0022407
biological_process
positive regulation of cell-cell adhesion
GO:0022409
activation of cell-cell adhesion
biological_process
stimulation of cell-cell adhesion
up regulation of cell-cell adhesion
up-regulation of cell-cell adhesion
upregulation of cell-cell adhesion
digestive system process
GO:0022600
biological_process
biological adhesion
GO:0022610
biological_process
signaling
cellular cation homeostasis
GO:0030003
biological_process
hemopoiesis
GO:0030097
Wikipedia:Haematopoiesis
biological_process
blood cell biosynthesis
blood cell formation
haemopoiesis
hematopoiesis
myeloid cell differentiation
endocytic vesicle
GO:0030139
NIF_Subcellular:sao1362520468
cellular_component
endocytotic transport vesicle
endocytotic vesicle
regulation of cell adhesion
GO:0030155
biological_process
cell adhesion receptor regulator activity
transcription regulator activity
1
GO:0000988
GO:0001071
GO:0006351
GO:0030528
This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
molecular_function
transcriptional regulator activity
intrinsic component of membrane
GO:0031224
Note that proteins intrinsic to membranes cannot be removed without disrupting the membrane, e.g. by detergent.
cellular_component
intrinsic to membrane
intrinsic component of plasma membrane
GO:0031226
cellular_component
intrinsic to plasma membrane
cytoplasmic vesicle
GO:0031410
NIF_Subcellular:sao180601769
cellular_component
ubiquitin protein ligase binding
GO:0031625
molecular_function
ubiquitin ligase binding
response to nutrient levels
GO:0031667
biological_process
vesicle
GO:0031982
NIF_Subcellular:sao221389602
Wikipedia:Vesicle_(biology)
cellular_component
membrane-bounded vesicle
GO:0031988
cellular_component
membrane-enclosed vesicle
regulation of intracellular transport
GO:0032386
biological_process
positive regulation of intracellular transport
GO:0032388
activation of intracellular transport
biological_process
stimulation of intracellular transport
up regulation of intracellular transport
up-regulation of intracellular transport
upregulation of intracellular transport
developmental process
GO:0032502
biological_process
development
RNA biosynthetic process
GO:0032774
Note that, in some cases, viral RNA replication and viral transcription from RNA actually refer to the same process, but may be called differently depending on the focus of a specific research study.
RNA anabolism
RNA biosynthesis
RNA formation
RNA synthesis
biological_process
regulation of homeostatic process
GO:0032844
biological_process
regulation of protein localization
GO:0032880
biological_process
regulation of protein localisation
regulation of intracellular protein transport
GO:0033157
biological_process
response to vitamin
GO:0033273
biological_process
protein localization to nucleus
cellular protein localization
intracellular signal transduction
somatodendritic compartment
locomotion
GO:0040011
biological_process
wound healing
GO:0042060
Wikipedia:Wound_healing
biological_process
regulation of cell proliferation
GO:0042127
biological_process
response to chemical
GO:0042221
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
biological_process
response to chemical stimulus
response to chemical substance
regulation of protein import into nucleus
GO:0042306
biological_process
regulation of protein import into cell nucleus
regulation of protein transport from cytoplasm to nucleus
regulation of protein-nucleus import
taxis
GO:0042330
Wikipedia:Taxis
biological_process
directed movement in response to stimulus
regulation of NF-kappaB import into nucleus
GO:0042345
biological_process
regulation of NF-kappaB import into cell nucleus
regulation of NF-kappaB transport from cytoplasm to nucleus
regulation of NF-kappaB-nucleus import
NF-kappaB import into nucleus
chemokine receptor binding
GO:0042379
chemokine receptor ligand
molecular_function
melanosome
GO:0042470
Wikipedia:Melanosome
cellular_component
response to drug
GO:0017035
GO:0042493
biological_process
drug resistance
drug susceptibility/resistance
regulation of apoptotic process
GO:0042981
Reactome:REACT_106248
Reactome:REACT_109234
Reactome:REACT_109339
Reactome:REACT_13648
Reactome:REACT_29911
Reactome:REACT_30641
Reactome:REACT_79698
Reactome:REACT_85908
Reactome:REACT_86575
Reactome:REACT_95946
Reactome:REACT_96201
Reactome:REACT_99944
This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used.
apoptosis regulator activity
biological_process
regulation of apoptosis
regulation of transcription factor import into nucleus
GO:0042990
biological_process
regulation of transcription factor import into cell nucleus
regulation of transcription factor transport from cytoplasm to nucleus
regulation of transcription factor-nucleus import
transcription factor import into nucleus
neuron projection
GO:0043005
NIF_Subcellular:sao-867568886
cellular_component
neurite
neuron process
neuron protrusion
neuronal cell projection
neuronal cell body
GO:0043025
NIF_Subcellular:sao1044911821
Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections.
Wikipedia:Soma_(biology)
cellular_component
neuron cell body
neuronal cell soma
positive regulation of apoptotic process
GO:0043065
This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is positively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used.
activation of apoptosis
biological_process
positive regulation of apoptosis
pro-apoptosis
stimulation of apoptosis
up regulation of apoptosis
up-regulation of apoptosis
upregulation of apoptosis
negative regulation of apoptotic process
GO:0006916
GO:0043066
Reactome:REACT_13537
Reactome:REACT_29981
Reactome:REACT_77563
Reactome:REACT_81263
Reactome:REACT_83278
Reactome:REACT_84567
Reactome:REACT_91585
Reactome:REACT_93662
Reactome:REACT_95215
Reactome:REACT_95867
Reactome:REACT_98500
This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is negatively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used.
anti-apoptosis
apoptosis inhibitor activity
biological_process
down regulation of apoptosis
down-regulation of apoptosis
downregulation of apoptosis
inhibition of apoptosis
negative regulation of apoptosis
pro-survival
regulation of programmed cell death
GO:0043067
GO:0043070
biological_process
regulation of non-apoptotic programmed cell death
positive regulation of programmed cell death
GO:0043068
GO:0043071
activation of programmed cell death
biological_process
positive regulation of non-apoptotic programmed cell death
stimulation of programmed cell death
up regulation of programmed cell death
up-regulation of programmed cell death
upregulation of programmed cell death
negative regulation of programmed cell death
GO:0043069
GO:0043072
biological_process
down regulation of programmed cell death
down-regulation of programmed cell death
downregulation of programmed cell death
inhibition of programmed cell death
negative regulation of non-apoptotic programmed cell death
receptor metabolic process
GO:0043112
biological_process
receptor metabolism
intracellular membrane-bounded organelle
GO:0043231
cellular_component
intracellular membrane-enclosed organelle
positive regulation of DNA binding
GO:0043388
activation of DNA binding
biological_process
stimulation of DNA binding
up regulation of DNA binding
up-regulation of DNA binding
upregulation of DNA binding
pigmentation
GO:0043473
biological_process
sequence-specific DNA binding
GO:0043565
molecular_function
sequence specific DNA binding
structure-specific DNA binding
GO:0043566
molecular_function
structure specific DNA binding
macromolecular complex subunit organization
GO:0034600
GO:0034621
GO:0043933
biological_process
cellular macromolecular complex organization
cellular macromolecular complex subunit organisation
cellular macromolecular complex subunit organization
macromolecular complex organization
macromolecular complex subunit organisation
regulation of system process
GO:0044057
biological_process
cellular macromolecule metabolic process
GO:0034960
GO:0044260
biological_process
cellular biopolymer metabolic process
cellular macromolecule metabolism
symbiosis, encompassing mutualism through parasitism
extracellular region part
GO:0044421
NIF_Subcellular:sao9117790637
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
cellular_component
extracellular structure
organelle part
GO:0044422
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
cellular_component
intracellular part
GO:0044424
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
cellular_component
cytoplasmic vesicle part
GO:0044433
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
cellular_component
cytoplasmic part
GO:0044444
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
cellular_component
cytoplasm component
plasma membrane part
GO:0044459
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
cellular_component
cell part
GO:0044464
NIF_Subcellular:sao628508602
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
cellular subcomponent
cellular_component
protoplast
single-organism process
2012-09-19T15:05:24Z
GO:0044699
biological_process
janelomax
single organism process
single organism signaling
single-organism cellular process
2012-12-11T16:56:55Z
GO:0044763
biological_process
janelomax
single-organism developmental process
2012-12-19T12:21:31Z
GO:0044767
biological_process
janelomax
regulation of viral genome replication
GO:0045069
biological_process
leukocyte activation
GO:0045321
Wikipedia:Immunologic_activation
biological_process
immune cell activation
leucocyte activation
regulation of cell differentiation
GO:0045595
biological_process
negative regulation of cell differentiation
GO:0045596
biological_process
down regulation of cell differentiation
down-regulation of cell differentiation
downregulation of cell differentiation
inhibition of cell differentiation
positive regulation of cell differentiation
GO:0045597
activation of cell differentiation
biological_process
stimulation of cell differentiation
up regulation of cell differentiation
up-regulation of cell differentiation
upregulation of cell differentiation
regulation of myeloid cell differentiation
GO:0045637
biological_process
positive regulation of myeloid cell differentiation
GO:0045639
activation of myeloid cell differentiation
biological_process
stimulation of myeloid cell differentiation
up regulation of myeloid cell differentiation
up-regulation of myeloid cell differentiation
upregulation of myeloid cell differentiation
negative regulation of transcription, DNA-templated
GO:0016481
GO:0032582
GO:0045892
GO:0061021
biological_process
down regulation of gene-specific transcription
down regulation of transcription, DNA-dependent
down-regulation of gene-specific transcription
down-regulation of transcription, DNA-dependent
downregulation of gene-specific transcription
downregulation of transcription, DNA-dependent
inhibition of gene-specific transcription
inhibition of transcription, DNA-dependent
negative regulation of cellular transcription, DNA-dependent
negative regulation of gene-specific transcription
negative regulation of transcription, DNA-dependent
transcription repressor activity
negative regulation of nucleobase-containing compound metabolic process
GO:0045934
biological_process
down regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
downregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
inhibition of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
regulation of nucleocytoplasmic transport
GO:0046822
biological_process
positive regulation of nucleocytoplasmic transport
GO:0046824
activation of nucleocytoplasmic transport
biological_process
stimulation of nucleocytoplasmic transport
up regulation of nucleocytoplasmic transport
up-regulation of nucleocytoplasmic transport
upregulation of nucleocytoplasmic transport
developmental pigmentation
GO:0048066
biological_process
pigmentation during development
blood vessel morphogenesis
GO:0048514
biological_process
negative regulation of biological process
GO:0043118
GO:0048519
biological_process
down regulation of biological process
down-regulation of biological process
downregulation of biological process
inhibition of biological process
negative regulation of physiological process
positive regulation of cellular process
GO:0048522
GO:0051242
activation of cellular process
biological_process
positive regulation of cellular physiological process
stimulation of cellular process
up regulation of cellular process
up-regulation of cellular process
upregulation of cellular process
negative regulation of cellular process
GO:0048523
GO:0051243
biological_process
down regulation of cellular process
down-regulation of cellular process
downregulation of cellular process
inhibition of cellular process
negative regulation of cellular physiological process
hematopoietic or lymphoid organ development
GO:0048534
biological_process
haematopoietic or lymphoid organ development
haemopoietic or lymphoid organ development
hemopoietic or lymphoid organ development
system development
GO:0048731
biological_process
pigment granule
GO:0048770
cellular_component
cell motility
GO:0048870
biological_process
cell locomotion
cell movement
movement of a cell
regulation of biological process
GO:0050789
GO:0050791
biological_process
regulation of physiological process
regulation of viral process
GO:0050792
biological_process
regulation of viral life cycle
regulation of viral reproduction
regulation of cellular process
GO:0050794
GO:0051244
biological_process
regulation of cellular physiological process
response to stimulus
GO:0050896
GO:0051869
Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
biological_process
physiological response to stimulus
pigment cell differentiation
GO:0043357
GO:0043358
GO:0050931
Note that the chromatophore mentioned here is distinct from the pigment bearing structure found in certain photosynthetic bacteria and cyanobacteria. It is also different from the plant chromoplast, which is also sometimes called a chromatophore.
biological_process
chromatophore differentiation
pigmented cell differentiation
regulation of transport
GO:0051049
biological_process
positive regulation of transport
GO:0051050
activation of transport
biological_process
stimulation of transport
up regulation of transport
up-regulation of transport
upregulation of transport
negative regulation of transport
GO:0051051
biological_process
down regulation of transport
down-regulation of transport
downregulation of transport
inhibition of transport
regulation of DNA metabolic process
GO:0051052
biological_process
regulation of DNA metabolism
regulation of sequence-specific DNA binding transcription factor activity
GO:0051090
Reactome:REACT_104536
Reactome:REACT_107559
Reactome:REACT_109535
Reactome:REACT_110257
Reactome:REACT_110693
Reactome:REACT_21326
Reactome:REACT_82719
Reactome:REACT_83365
Reactome:REACT_90659
Reactome:REACT_92725
Reactome:REACT_96476
Reactome:REACT_99415
biological_process
regulation of transcription factor activity
positive regulation of developmental process
GO:0051094
activation of developmental process
biological_process
stimulation of developmental process
up regulation of developmental process
up-regulation of developmental process
upregulation of developmental process
regulation of binding
GO:0051098
biological_process
positive regulation of binding
GO:0051099
activation of binding
biological_process
stimulation of binding
up regulation of binding
up-regulation of binding
upregulation of binding
regulation of DNA binding
GO:0051101
biological_process
negative regulation of cellular component organization
GO:0051129
biological_process
down regulation of cell organization
down-regulation of cell organization
downregulation of cell organization
inhibition of cell organization
negative regulation of cell organisation
negative regulation of cellular component organization and biogenesis
regulation of nitrogen compound metabolic process
GO:0051171
biological_process
regulation of nitrogen metabolic process
regulation of nitrogen metabolism
negative regulation of nitrogen compound metabolic process
GO:0051172
biological_process
down regulation of nitrogen metabolic process
down-regulation of nitrogen metabolic process
downregulation of nitrogen metabolic process
inhibition of nitrogen metabolic process
negative regulation of nitrogen metabolic process
negative regulation of nitrogen metabolism
positive regulation of nitrogen compound metabolic process
GO:0051173
activation of nitrogen metabolic process
biological_process
positive regulation of nitrogen metabolic process
positive regulation of nitrogen metabolism
stimulation of nitrogen metabolic process
up regulation of nitrogen metabolic process
up-regulation of nitrogen metabolic process
upregulation of nitrogen metabolic process
localization
GO:0051179
biological_process
establishment and maintenance of cellular component location
establishment and maintenance of localization
establishment and maintenance of position
establishment and maintenance of substance location
establishment and maintenance of substrate location
localisation
positive regulation of protein transport
GO:0051222
activation of protein transport
biological_process
stimulation of protein transport
up regulation of protein transport
up-regulation of protein transport
upregulation of protein transport
regulation of protein transport
GO:0051223
biological_process
negative regulation of RNA metabolic process
GO:0051253
biological_process
down regulation of RNA metabolic process
down-regulation of RNA metabolic process
downregulation of RNA metabolic process
inhibition of RNA metabolic process
negative regulation of RNA metabolism
cellular localization
localization of cell
GO:0051674
biological_process
cell localization
establishment and maintenance of cell localization
establishment and maintenance of localization of cell
localisation of cell
cellular response to stimulus
response to protein
1
GO:0006986
GO:0009725
GO:0034097
GO:0051788
GO:0051789
GO:0070848
This term was made obsolete because more specific terms exist.
biological_process
response to protein stimulus
metal ion homeostasis
GO:0055065
biological_process
di-, tri-valent inorganic cation homeostasis
1
GO:0055066
GO:0072507
GO:0072508
This term was made obsolete because it has been split.
biological_process
calcium ion homeostasis
GO:0055074
biological_process
regulation of calcium ion concentration
cation homeostasis
GO:0055080
biological_process
regulation of macromolecule metabolic process
GO:0060255
biological_process
cell chemotaxis
negative regulation of cell death
2009-04-13T01:56:10Z
GO:0060548
biological_process
dph
macromolecular complex assembly
GO:0065003
biological_process
macromolecule complex assembly
regulation of molecular function
GO:0065009
biological_process
regulation of a molecular function
regulation of establishment of protein localization
GO:0070201
biological_process
regulation of establishment of protein localisation
protein complex biogenesis
GO:0070271
biological_process
protein complex biogenesis and assembly
response to oxygen levels
GO:0070482
biological_process
cell periphery
cardiovascular system development
divalent inorganic cation homeostasis
2010-12-16T03:22:48Z
GO:0072507
Note that this term was split from 'di-, tri-valent inorganic cation homeostasis ; GO:0055066' (sibling term 'trivalent inorganic cation homeostasis' ; GO:0072508').
biological_process
midori
inflammatory response to wounding
neuron part
2012-12-19T16:53:50Z
GO:0097458
cellular_component
paola
leaflet of membrane bilayer
side of membrane
2013-12-03T11:28:04Z
GO:0098552
cellular_component
davidos
regulation of cytoplasmic transport
2014-11-24T13:38:17Z
GO:1903649
biological_process
jl
regulation of cytoplasmic streaming
regulation of hemopoiesis
2014-12-04T15:34:13Z
An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype.
GO:1903706
biological_process
pad
regulation of blood cell biosynthesis
regulation of blood cell formation
regulation of haemopoiesis
regulation of hematopoiesis
positive regulation of hemopoiesis
2014-12-04T15:34:30Z
An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype.
GO:1903708
activation of blood cell biosynthesis
activation of blood cell formation
activation of haemopoiesis
activation of hematopoiesis
activation of hemopoiesis
biological_process
pad
positive regulation of blood cell biosynthesis
positive regulation of blood cell formation
positive regulation of haemopoiesis
positive regulation of hematopoiesis
up regulation of blood cell biosynthesis
up regulation of blood cell formation
up regulation of haemopoiesis
up regulation of hematopoiesis
up regulation of hemopoiesis
up-regulation of blood cell biosynthesis
up-regulation of blood cell formation
up-regulation of haemopoiesis
up-regulation of hematopoiesis
up-regulation of hemopoiesis
upregulation of blood cell biosynthesis
upregulation of blood cell formation
upregulation of haemopoiesis
upregulation of hematopoiesis
upregulation of hemopoiesis
regulation of cellular protein localization
2015-01-20T14:32:14Z
GO:1903827
biological_process
jl
regulation of cellular protein localisation
regulation of channel localizer activity